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KMID : 1007520220310010111
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Food Science and Biotechnology
2022 Volume.31 No. 1 p.111 ~ p.120
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Effects of Lactobacillus curvatus MG5246 on inflammatory markers in Porphyromonas gingivalis lipopolysaccharide-sensitized human gingival fibroblasts and periodontitis rat model
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Jung Jae-In
Kim Yong-Gyeong
Kang Chang-Ho
Imm Jee-Young
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Abstract
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This study investigated the effects of Lactobacillus curvatus MG5246 on periodontitis inflammation. Cell-free supernatants (CFS) prepared from L. curvatus MG5246 decreased prostaglandin E2 production and cyclooxygenase-2 gene expression by 60% and 78% in Porphyromonas gingivalis-lipopolysaccharide stimulated human gingival fibroblasts at 400 μg/mL. Gene expressions of tumor necrosis factor-α, interleukin-6, matrix metalloproteinases, and chemokines were significantly downregulated by CFS treatment (p?
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KEYWORD
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Lactobacillus curvatus MG5246, Human gingival fibroblasts, Inflammatory cytokine, Chemokine, Ligature-induced periodontitis rat
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